DISCLAIMER: SARM's are not intended for human consumption and are not approved by, or otherwise endorsed by the US Food and Drug Administration. The introduction of SARMs has been a recent advancement in performance-enhancing drugs with anabolic effects on the muscle without adverse effects on other tissues. These compounds are currently in various stages of development, and their use is only legal for research purposes at this time. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Non-steroidal SARMs differ from testosterone in that they are unable to convert to metabolites while retaining the ability to act as agonists for bone and muscle tissue. Selective Androgenic Receptor Modulators have also been tested for potential use with breast cancer survivors due to their lower risk of gynecomastia despite anabolic effects on skeletal muscles; however, data has shown these drugs may result in the development of prostate enlargement or hyperplasia which can lead to higher levels of unwanted estrogen exposure. They also produce less suppression than testosterone at hypothalamic sites resulting in more libido problems like erectile dysfunction and decreased ejaculation frequency.
SARMs change the way that genes express themselves. This is because different they change the shape of your cells and they can perform different actions on cells. So, when it interacts with the androgen receptor, which is one of the receptors inside the cell, it changes how the gene expresses itself. The inherent anabolic properties of SARMs are what makes them ideal for testosterone (TRT) users who are looking to build more muscle mass and increase their strength. But with the risk of adverse effects like prostate enlargement or hyperplasia, it's best to consult your doctor and find out whether this might be right for you before taking any drugs. The main attraction of non-steroidal SARMs is that they can be taken orally without adverse effects on liver or kidney function, unlike anabolic steroids which are typically injected. This makes them more suitable for therapeutic use than oral AASs (Androgenic Anabolic Steroids). Currently, there are over 100 types of research chemicals sold online under various names with unknown side effects on long-term usage. Due to this limited information about their safety profile and lack of clinical trials/research data available it would seem impossible at this time for conclusive data.
Most people ingest these compounds as oral capsules, but there are other ways that they can be administered depending on how serious someone wants to get about using these performance-enhancing drugs. Some drink it in a liquid form while others inject it into themselves with needles (injectable SARMs). At Sarmmies™, we formulate a proprietary NeoColloid® Gel-Matrix (which is just fancy for bio-engineered gummy). This gel matrix holds various performance/anabolic enhancing compounds such as the popular RAD140 (Testolone), LGD-4033 (Ligandrol), MK-2866 (Ostarine/Enobosarm), SR9009 (Stenabolic), and even non-SARM compounds like MK-677 (Ibutamoren), and GW501516 (Cardarine).
FDA DISCLAIMER: SARM's are not intended for human consumption and are not approved by, or otherwise endorsed by the US Food and Drug Administration. The introduction of SARMs has been a recent advancement in performance-enhancing drugs with anabolic effects on the muscle without adverse effects on other tissues. These compounds are currently in various stages of development, and their use is only legal for research purposes at this time.
SARMs have been linked to many of the same harmful side effects as steroids. But what if you could limit those by choosing a SARMS that only attaches to muscle or liver receptors? It's possible, but it would be better not too get your hopes up since this is still in its early stages and has yet to prove itself for either safety or effectiveness.
SARMS are an emerging class of performance-enhancing drugs similar in structure and mechanism of action (binding) with testosterone which binds selectively on Androgenic Receptor Modulators (APR). While there were some initial reports suggesting they may provide therapeutic benefits without adverse consequences compared with traditional hormones when used at appropriate dose levels; however these findings need further confirmation using population level studies.
At present, SARMs are not illegal as they have yet to be classified by the DEA. However, there is a great deal of controversy surrounding them and their use in athletic contests such as bodybuilding competitions; for example, an athlete who tests positive for SARMs while competing will permanently lose his title."
- Selective Androgenic Receptor Modulators
- performance-enhancing drugs
- anabolic
"Nonsteroidal SARMs differ from testosterone chiefly due to their inability to convert to active metabolites," "SARMS are not illegal but face heavy scrutiny because they offer advantages over other banned substances like testosterone without steroids which can damage your liver or cause cancer."
RAD140 is an orally available, non-steroidal [§2 - T.O.U.] SARM that is the subject of ongoing preclinical and clinical studies, designed to artificially augment testosterone [§2 - T.O.U.] (particularly in low-T patients [§2 - T.O.U.]) in an effort to increase androgen-responsive tissues.
GW501516 is a potent PPARβ (peroxisome proliferator-activated receptor) agonist that exhibits 1,000-fold more selectivity than existing subtypes and has been shown to regulate gene expression in lipid catabolism.
The MK-2866 selective androgen receptor modulator (GTx-024) selectively targets muscle cells with an affinity of 3.8 nM and exhibits (research suggests) the ability to increase lean body mass, decrease fat deposition, and improve bone density among subjects [§2 - T.O.U.] in good physical condition.
MK-677 is a drug that mimics growth hormone [§2 - T.O.U.] by binding to and activating the ghrelin receptor (i.e, ghrelin receptor agonist). This particular compound has been ostensibly called the "holy grail of aging research." [§2 - T.O.U.]
